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New gene activation tool may do what CRISPR cannot: Work inside the body
The ability to precisely adjust the expression of genes inside the human body—ramping up protective ones and tamping down harmful ones—holds enormous potential for treating and preventing disease.
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Sharpening an essential tool for biotechnology
Scientists at the Department of Energy (DOE)'s Oak Ridge National Laboratory (ORNL) have shown that more than 93% of possible E. coli CRISPR-Cas9 guide RNAs—molecules that direct the gene-editing CRISPR tool to the right spot in DNA—work as intended, a far higher percentage than
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